Infectious Disease

Post COVID-19 Condition

The COVID-19 pandemic brought global awareness to the seriousness of viral infection and the severity it can have on our bodies and minds. “Long COVID” remains a symptom of approximately 30% of individuals who got infected with the COVID-19 virus, which no cure has been identified.

We are researching phytochemicals and micro-nutrients which may mitigate and alleviate side-effects of viral infection, such as Post COVID-19 Condition.

TLS-2

Reduction of associated inflammation and ROS

Nrf2 activation. ACE2 inhibition

Wholly-owned

Infectious Disease

HIV/AIDS

HIV/AIDS is known as a disease of exceptionalism, due to its complex assault on the body’s immune system. A substantial library of evidence suggest phytochemicals may have positive attribution of effect on the HIV/AIDS virus and people living with AIDS.

TLS-1

Modulation of Systemic Chronic Inflammation

Nrf2, MAPK activation. TNFa, IL-1β regulation.

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Neurocognitive

Natural compounds, such as flavonoids, possess neuroprotective potential likely related to their ability to modulate the inflammatory responses involved in neurodegenerative diseases.

HIV/AIDS Neurcognitive Disfunction (HAND)

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Neuro-inflammation

Tau protein, Tat protein, Sirtuin modulation

Wholly-owned

Gerosciences

Old age is the greatest risk factor for the chronic diseases responsible for the majority of morbidity, mortality, and health-care costs worldwide. These chronic diseases include atherosclerosis and other cardiovascular diseases, strokes, dementias, most cancers, diabetes, renal failure, chronic lung diseases, osteoporosis, arthritis, blindness, and neurodegenerative diseases. Aging also predis-poses people to geriatric syndromes and decreased physical resilience. The geriatric syndromes include frailty, sarcopenia, immobility, falling, depression, mild cognitive impairment, incontinence, metabolic syndrome, and weight loss. Decreased physical resilience can be reflected in delayed recovery following myocardial infarction, stroke, injuries, infection, chemotherapy, surgery, or fractures and in impaired response to immunization. Combinations of these conditions often occur in older individuals, with the frequency of multimorbidity (three or more conditions occurring simultaneously) increasing exponentially in the third tertile of life. The presence of multimorbidity confounds the potential gains from curing any single age-related disorder.

Aging

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders as well as chronic obstructive pulmonary disease, chronic kidney disease, osteoporosis, sarcopenia, stroke and many others . Primary drivers of aging are telomere damage, epigenetic dysregulation, DNA damage, and mitochondrial dysfunction.

TLS-4

Mitochondrial toxicity

FOXO3, CD4 T Cells From ART-Controlled PLHIV

Wholly-owned

Gerosciences

Aging

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders as well as chronic obstructive pulmonary disease, chronic kidney disease, osteoporosis, sarcopenia, stroke and many others.

Recent science is starting to understand the role that certain phytochemicals can support optimal mitochondrial function, remove senescent cells, and encourage telomere length, all which support healthy aging

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Telomerase and Telomere modulation

Telomeres are dynamic nucleoprotein structures that protect the ends of chromosomes from degradation and activation of the DNA damage response. Telomeres are considered to be a biological clock, playing a major role in aging and genome stability. It is now well-documented that telomere dysfunction is a potential biomarker for age-related diseases and can contribute to the prognosis of several diseases. A link between telomere shortening and oxidative stress was found in aging people and patients with cancer or inflammatory diseases.

Telomeric G-quadruplex DNA Tel7 sequence

Wholly-owned

Gerosciences

Old age is the greatest risk factor for the chronic diseases responsible for the majority of morbidity, mortality, and health-care costs worldwide. These chronic diseases include atherosclerosis and other cardiovascular diseases, strokes, dementias, most cancers, diabetes, renal failure, chronic lung diseases, osteoporosis, arthritis, blindness, and neurodegenerative diseases. Aging also predis-poses people to geriatric syndromes and decreased physical resilience. The geriatric syndromes include frailty, sarcopenia, immobility, falling, depression, mild cognitive impairment, incontinence, metabolic syndrome, and weight loss. Decreased physical resilience can be reflected in delayed recovery following myocardial infarction, stroke, injuries, infection, chemotherapy, surgery, or fractures and in impaired response to immunization. Combinations of these conditions often occur in older individuals, with the frequency of multimorbidity (three or more conditions occurring simultaneously) increasing exponentially in the third tertile of life. The presence of multimorbidity confounds the potential gains from curing any single age-related disorder.

Aging

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders as well as chronic obstructive pulmonary disease, chronic kidney disease, osteoporosis, sarcopenia, stroke and many others . Primary drivers of aging are telomere damage, epigenetic dysregulation, DNA damage, and mitochondrial dysfunction.

TLS-4

Mitochondrial toxicity

FOXO3, CD4 T Cells From ART-Controlled PLHIV

Wholly-owned

Senotherapeutic

Aging

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Senolytics

Accumulation of senescent endothelial cells is associated with impaired tight junction structure and compromised blood-brain barrier integrity and it is linked to Sirt1 downregulation in senescent endothelial cells

Microglia, Oligodendrocytes,

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