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The Science

Plant compounds, such as flavonoids, alkaloids, terpenoids and polyphenolic compounds, hold great promise in advancing therapeutics to address disease related complications.

Address the system, not just the symptom.

Systemic Chronic Inflammation (SCI)

Inflammation is the root cause of 95% of all major diseases.  We are creating phyto-compound based therapeutics to help patients achieve inflammatory homeostasis.

Infectious Disease

  • Disease related malnutrition and subsequent systemic chronic inflammation are closely associated with infectious disease.
  • Plant compounds, such as flavonoids, have been shown to be effective in facilitating the regulation of inflammatory responses.iii
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Geroscience

  • Aging happens and the contributions to age-related diseases are many.
  • Polyphenol are proven to slow accelerated aging and we are developing novel therapeutics to help us ward off the inevitable.
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Geroscience

  • Aging happens and the contributions to age-related diseases are many.
  • Polyphenols are proven to slow accelerated aging and we are developing novel therapeutics to help us ward off the inevitable.

Mitochondrial health

  • Emerging research suggests that the mitochondria are essential to almost every cellular activity in the body.
  • We are developing plant-based therapeutics to address deficiencies that may lead to compromised mitochondrial function and toxicity.

Mitochondrial health

  • Emerging research suggests that the mitochondria are essential to almost every cellular activity in the body.
  • We are developing plant-based therapeutics to address deficiencies that may lead to compromised mitochondrial function and toxicity.
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Telomeres

  • Research suggests that preserving telomere length has the potential to prevent and treat diseases associated with aging.
  • Clinical research strongly supports the use of phytochemical compounds to preserve telomere length.

Neurodegenerative disease and support

It is unlikely that a single change will be effective at treating neurodegeneration, as several changes occur in the development of NDs.

The potential to treat neurodegenerative diseases (NDs) with phyto compounds is well documented. Numerous findings now suggest flavonoids target protein misfolding and aggregation, a common cause and pathological mechanism in many NDs.

Oncology

  • Enough evidence supports flavonoids may be an important adjuvant in cancer therapy, highlighting the importance of healthy and balanced diets to prevent the onset and progression of the disease.
  • Flavonoids can inhibit inflammation and increase immunity, modulating the NF-κB, MAPK, inflammasome, and JAK-STAT pathways, which are usually altered in cancer.vi,vii,viii,ix,x

Oncology

  • Enough evidence supports flavonoids may be an important adjuvant in cancer therapy, highlighting the importance of healthy and balanced diets to prevent the onset and progression of the disease.
  • Flavonoids can inhibit inflammation and increase immunity, modulating the NF-κB, MAPK, inflammasome, and JAK-STAT pathways, which are usually altered in cancer.vi,vii,viii,ix,x
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Flavonoids are polyphenolic plant secondary metabolites with pleiotropic biological properties. Studies demonstrate that flavonoids synergistically enhance the effects of canonical chemotherapeutics.xi

CLINICAL STUDIES

Trility is preparing to participate in clinical studies with our initial enteral formula, ACEND, focusing on People Living with HIV (PLWH) and modulation of disease related malnutrition and subsequent systemic chronic inflammation.

References

References

i. https://www.health.harvard.edu/staying-healthy/inflammation-a-unifying-theory-of-disease

ii. https://www.nature.com/articles/s41591-019-0675-0

iii. Russo M, Moccia S, Spagnuolo C, Tedesco I, Russo GL. Roles of flavonoids against coronavirus infection. Chem Biol Interact. 2020 Sep 1;328:109211. doi: 10.1016/j.cbi.2020.109211. Epub 2020 Jul 28. PMID: 32735799; PMCID: PMC7385538.

iv. Monjotin N, Amiot MJ, Fleurentin J, Morel JM, Raynal S. Clinical Evidence of the Benefits of Phytonutrients in Human Healthcare. Nutrients. 2022 Apr 20;14(9):1712. doi: 10.3390/nu14091712. PMID: 35565680; PMCID: PMC9102588.

v. Fan X, Fan Z, Yang Z, Huang T, Tong Y, Yang D, Mao X, Yang M. Flavonoids-Natural Gifts to Promote Health and Longevity. Int J Mol Sci. 2022 Feb 16;23(4):2176. doi: 10.3390/ijms23042176. PMID: 35216290; PMCID: PMC8879655.

vi. Shay J, Elbaz HA, Lee I, Zielske SP, Malek MH, Hüttemann M. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260. doi: 10.1155/2015/181260. Epub 2015 Jun 9. PMID: 26180580; PMCID: PMC4477097.

vii. Peng L, Liu A, Shen Y, Xu HZ, Yang SZ, Ying XZ, Liao W, Liu HX, Lin ZQ, Chen QY, Cheng SW, Shen WD. Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway. Oncol Rep. 2013 Feb;29(2):571-8. doi: 10.3892/or.2012.2165. Epub 2012 Dec 4. PMID: 23232982.

viii. Jiang ZB, Wang WJ, Xu C, Xie YJ, Wang XR, Zhang YZ, Huang JM, Huang M, Xie C, Liu P, Fan XX, Ma YP, Yan PY, Liu L, Yao XJ, Wu QB, Lai-Han Leung E. Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer. Cancer Lett. 2021 Sep 1;515:36-48. doi: 10.1016/j.canlet.2021.05.019. Epub 2021 May 28. PMID: 34052328.

ix. Yao W, Gong H, Mei H, Shi L, Yu J, Hu Y. Taxifolin Targets PI3K and mTOR and Inhibits Glioblastoma Multiforme. J Oncol. 2021 Aug 20;2021:5560915. doi: 10.1155/2021/5560915. PMID: 34462635; PMCID: PMC8403040.

x. Yang D, Wang T, Long M, Li P. Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine. Oxid Med Cell Longev. 2020 Dec 30;2020:8825387. doi: 10.1155/2020/8825387. PMID: 33488935; PMCID: PMC7790550.

xi. Zhai K, Mazurakova A, Koklesova L, Kubatka P, Büsselberg D. Flavonoids Synergistically Enhance the Anti-Glioblastoma Effects of Chemotherapeutic Drugs. Biomolecules. 2021 Dec 7;11(12):1841. doi: 10.3390/biom11121841. PMID: 34944485; PMCID: PMC8699565

Telemere Lymphocytes Chart: Modifies from J. Exp. Med 2014 Vol.211 No.13. PIK3R1 mutation augments P12K signating in new PID [Lucas et al.]